| Pair Name | Gamma-Tocotrienol, Simvastatin | ||
| Phytochemical Name | Gamma-Tocotrienol (PubChem CID: 5282349 ) | ||
| Anticancer drug Name | Simvastatin (PubChem CID: 54454 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gamma-Tocotrienol, Simvastatin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Down-regulation | Expression | MYC | hsa4609 | |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| In Vitro Model | NCI-ADR-RES | High grade ovarian serous adenocarcinoma | Homo sapiens (Human) | CVCL_1452 |
| MCF-7/TAMR-1 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_M436 | |
| Result | Data demonstrate that SVA and γT3 alone or in combination possess the ability to eliminate CSCs in drug resistant human breast cancer cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. Cancer Lett. 2013 Jan 28;328(2):285-96. doi: 10.1016/j.canlet.2012.10.003. | Click |
